concept

NAD+ METABOLISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAD+ METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

0Hypotheses

1Analyses

5Outgoing

50Incoming

0Experiments

2Debates

No summary available yet.

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💡 Concept Info

Name	NAD+ METABOLISM

Pathway Diagram

graph TD
    NAD__METABOLISM[NAD+ METABOLISM]
    NAD__METABOLISM -->|drives| cancer[cancer]
    NAD__METABOLISM -->|regulates| immune_system[immune system]
    NAD__METABOLISM -->|regulates| aging[aging]
    NAD__METABOLISM -->|regulates| Stemness[Stemness]
    SIRT1[SIRT1] -->|participates in| NAD__METABOLISM
    nicotinamide[nicotinamide] -->|modulates| NAD__METABOLISM
    neurodegeneration[neurodegeneration] -->|involves| NAD__METABOLISM
    NAD[NAD] -->|participates in| NAD__METABOLISM
    neurons[neurons] -->|active_in| NAD__METABOLISM
    NADH[NADH] -->|participates in| NAD__METABOLISM
    DAM_microglia[DAM microglia] -->|active_in| NAD__METABOLISM
    AMPK[AMPK] -->|participates in| NAD__METABOLISM
    ATP[ATP] -->|participates in| NAD__METABOLISM
    CD38[CD38] -->|regulates| NAD__METABOLISM

Outgoing (5)

Target	Relation	Type	Str
cancer	drives	disease	0.85
immune system	regulates	pathway	0.85
aging	regulates	process	0.85
Aging-Associated Diseases	associated_with	disease	0.80
Stemness	regulates	phenotype	0.75

Incoming (63)

Source	Relation	Type	Str
AMPK	participates_in	gene	0.85
ATP	participates_in	gene	0.85
neurodegeneration	involves	disease	0.85
SIRT1	participates_in	gene	0.85
nicotinamide	modulates	drug	0.85
NAD	participates_in	gene	0.85
neurons	active_in	cell_type	0.85
NADH	participates_in	gene	0.85
DAM microglia	active_in	cell_type	0.85
CD38	regulates	gene	0.80
resveratrol	modulates	drug	0.75
APP	participates_in	gene	0.75
PARP1	participates_in	gene	0.75
SIRT3	participates_in	gene	0.75
NRF1	participates_in	gene	0.75
TFAM	participates_in	gene	0.75
FOXO3	participates_in	gene	0.75
NAMPT	participates_in	gene	0.75
DNA	participates_in	gene	0.75
Alzheimer's disease	involves	disease	0.75
PS1	participates_in	gene	0.75
astrocytes	active_in	cell_type	0.75
microglia	active_in	cell_type	0.65
Parkinson's disease	involves	disease	0.65
FOXO	participates_in	gene	0.65
metformin	modulates	drug	0.65
BMAL1	participates_in	gene	0.65
neuroinflammation	involves	disease	0.65
CLOCK	participates_in	gene	0.65
SIRT6	participates_in	gene	0.65
ATG5	participates_in	gene	0.55
LC3	participates_in	gene	0.55
ATG7	participates_in	gene	0.55
HK2	participates_in	gene	0.55
TNF	participates_in	gene	0.55
SIRT7	participates_in	gene	0.55
NRF2	participates_in	gene	0.55
APOE4	participates_in	gene	0.55
PGC1A	participates_in	gene	0.55
TET2	participates_in	gene	0.55
ROS	participates_in	gene	0.55
stem cells	active_in	cell_type	0.55
ACC	participates_in	gene	0.55
Huntington's disease	involves	disease	0.55
HIF	participates_in	gene	0.55
PPARA	participates_in	gene	0.55
SREBF1	participates_in	gene	0.55
PPARGC1A	participates_in	gene	0.55
HDAC3	participates_in	gene	0.55
RNA	participates_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.984

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning NAD+ METABOLISM in their description or question text

No additional research found