| Gene Symbol | LRP5 |
| Aliases | Page for LRP5 Protein |
| Protein Type | Receptor |
| Function | Wnt Binding: LRP5 binds Wnt ligands (Wnt1, Wnt3, Wnt3a) in conjunction with Frizzled receptors |
| Primary Expression | the central nervous system where it plays important roles in neuronal development, synaptic plasticity, and cognitive function[@gong2001] |
| Molecular Weight | 179 kDa |
| Amino Acids | 1615 aa |
| Pathways | Wnt, Wnt signaling, Wnt Signaling |
| UniProt ID | [O75177](https://www.uniprot.org/uniprot/O75177) |
| Ensembl ID | ENSG00000162337 |
| GeneCards | LRP5 |
| Human Protein Atlas | LRP5 |
| Wnt binding | Binds Wnt ligands (Wnt1, Wnt3, Wnt3a, Wnt5a) |
| Frizzled interaction | Forms receptor complexes with Frizzled proteins |
| β-catenin stabilization | Initiates canonical Wnt/β-catenin signaling |
| Associated Diseases | Aging, Als, Atherosclerosis, Autosomal Dominant Polycystic Kidney Diseases, Autosomal Dominant Polycystic Liver Diseases |
| Interactions | Actin, AMYLOID, APOE, APOE3, APOE4, App |
| KG Connections | 119 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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