gene

IGF2BP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF2BP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

250Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IGF2BP1 (IMP1/CRD-BP) is an RNA-binding protein with six KH domains that regulates mRNA localization, stability, and translation in neurons. Implicated in ALS, PD, and AD through RNA metabolism and stress granule dynamics.

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🧬 Gene Info

Gene Symbol	IGF2BP1
Full Name	Insulin-Like Growth Factor 2 mRNA-Binding Protein 1
Aliases	IMP1/CRD-BP
Chromosome	17q21.32
Function	is a member of the IMP family of RNA-binding proteins.
Molecular Weight	75 kDa
Amino Acids	660 aa
Exons	17
Pathways	Larval Brain Development, Neural Fate Specification, Neural Progenitor Patterning
UniProt ID	Q9Y296
NCBI Gene ID	10682
Ensembl ID	ENSG00000159248
OMIM	608288
GeneCards	IGF2BP1
Human Protein Atlas	IGF2BP1
Associated Diseases	Aging, Als, Cancer, Ftd, Neurodegeneration
Known Drugs/Compounds	N6-Methyladenosine
Interactions	ANK2, COMPLEMENT, ELAVL2, FUS, G3BP1, HNRNPA2B1
KG Connections	245 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IGF2BP1 — AlphaFold Q9Y296 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IGF2BP1

gene · 1597 words

→

IGF2BP1 Protein

protein · 1584 words

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Pathway Diagram

graph TD
    IGF2BP1["IGF2BP1"]
    IGF2BP1 -->|"binds"| p38_MAPK["p38 MAPK"]
    IGF2BP1 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    IGF2BP1 -->|"target for"| Aging["Aging"]
    IGF2BP1 -->|"target for"| Ms["Ms"]
    IGF2BP1 -->|"target for"| Als["Als"]
    IGF2BP1 -->|"target for"| Cancer["Cancer"]
    IGF2BP1 -->|"activates"| Carcinoma["Carcinoma"]
    IGF2BP1 -->|"activates"| Tumor["Tumor"]
    ELAVL2["ELAVL2"] -->|"target for"| IGF2BP1
    C1Q["C1Q"] -->|"target for"| IGF2BP1
    MTOR["MTOR"] -->|"target for"| IGF2BP1
    CLPP["CLPP"] -->|"target for"| IGF2BP1
    RAB11["RAB11"] -->|"target for"| IGF2BP1
    STX17["STX17"] -->|"target for"| IGF2BP1
    RAB5["RAB5"] -->|"target for"| IGF2BP1
    SNAP29["SNAP29"] -->|"target for"| IGF2BP1
    HNRNPA2B1["HNRNPA2B1"] -->|"interacts"| IGF2BP1
    PI3K["PI3K"] -->|"target for"| IGF2BP1

Outgoing (172)

Target	Relation	Type	Str
Neural Progenitor Temporal Patterning	involved_in	process	0.95
Neural Progenitor Patterning	involved_in	process	0.95
Larval Brain Development	involved_in	process	0.95
N6-Methyladenosine	binds	compound	0.95
neural progenitor temporal patterning	regulates	process	0.95
postembryonic neurogenesis	involved_in	process	0.90
Neurodevelopmental Mrnas	binds	biomarker	0.90
m6A Modification	binds	process	0.90
Temporal Regulators	regulates	process	0.90
Temporal Neural Fate Specification	regulates	process	0.90
Neural Diversity Generation	involved_in	process	0.88
SYNCRIP	interacts_with	protein	0.85
Neural Fate Specification	contributes_to	process	0.85
Subcellular Targeting	regulates	process	0.85
Neural Fate Specification	involved_in	process	0.85
neural fate specification	mediates	process	0.85
temporal regulators	associated_with	protein	0.80
Neural Diversity	contributes_to	phenotype	0.80
RNA stability	regulates	process	0.80
p38 MAPK	binds	protein	0.80
Ftd	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Aging	encodes	disease	0.65
Als	encodes	disease	0.65
Neurodegeneration	encodes	disease	0.65
Autism	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Ftd	therapeutic_target	disease	0.65
ALS	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
LYSOSOME	therapeutic_target	gene	0.60
Protein Aggregation	therapeutic_target	pathway	0.60
Interneuron	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Tdp-43	associated_with	pathway	0.60

Incoming (78)

Source	Relation	Type	Str
AUTOPHAGY	therapeutic_target	gene	0.60
C1Q	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
RAB11	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
RAB5	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
AKT	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
LYSOSOME	therapeutic_target	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
WNT	therapeutic_target	gene	0.60
WNT	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
HNRNPA2B1	interacts_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
TDP-43	therapeutic_target	gene	0.60
G3BP1	associated_with	gene	0.60
WTAP	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
METTL3	contributes_to	gene	0.60
GENES	contributes_to	gene	0.60
WTAP	contributes_to	gene	0.60
AGING	associated_with	gene	0.60
LONP1	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
ALS	encodes	gene	0.60
LYSOSOME	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60
METTL3	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
FUS	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
C1Q/C3	associated_with	gene	0.60
RAB11	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
STX17	associated_with	gene	0.60
ELAVL2	regulates	entity	0.60
FUS	regulates	entity	0.60
ALKBH5	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IGF2BP1 in their description or question text

No additional research found