| Gene Symbol | IL21 |
| Chromosome | 4q27 |
| Function | is a potent immunomodulatory cytokine belonging to the common gamma-chain receptor family, encoded by the IL21 gene located on chromosome 4q27 [1](https://www. |
| Primary Expression | multiple cell types: - Lymphocytes: B cells, T cells, NK cells - Myeloid cells: Macrophages, dendritic cells - Non-hematopoietic: Some epi |
| Pathways | JAK-STAT Pathway, PI3K, MAPK pathway, TGF-β |
| Ensembl ID | ENSG00000138618 |
| GeneCards | IL21 |
| Human Protein Atlas | IL21 |
| Lymphocytes | B cells, T cells, NK cells |
| Myeloid cells | Macrophages, dendritic cells |
| Non-hematopoietic | Some epithelial and stromal cells 6 |
| JAK1 and JAK3 | Associated with IL21R and γc chains |
| STAT3 | Primary transcription factor activated |
| STAT5 | Also activated in some cell types |
| PI3K-AKT and MAPK pathways | Contributing to cell survival and proliferation 7 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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