gene 2,764 words KG: IL27
Contents

IL27 — Interleukin 27

🧬 Gene Info
Gene SymbolIL27
Full NameInterleukin 27
Chromosome16p11.2
Protein TypeReceptor
FunctionInterleukin 27 (IL-27) is a cytokine belonging to the IL-12 family that plays complex roles in immune modulation, inflammation, and neuroinflammation
Primary Expressionvarious tissues and cell types:
PathwaysPI3K, MAPK, JAK-STAT
UniProt IDQ8N5L0
NCBI Gene ID246778
Ensembl IDENSG00000163512
OMIM607073
GeneCardsIL27
Human Protein AtlasIL27
p28 (IL-27p28)the α chain, encoded by IL27 gene
EBI3 (EBV-induced gene 3)the β chain, shared with IL-35
Associated Diseasesneurodegeneration
KG Connections4 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (13)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (4 edges)

IL27 activates Co-inhibitory Gene Module
IL27 drives co-inhibitory gene module
IL27 regulates non-responsive T cells
ADORA2A associated_with IL27

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