gene 2,068 words KG: IL23A
Contents

IL23A Gene

🧬 Gene Info
Gene SymbolIL23A
Full NameInterleukin 23 Subunit Alpha
Chromosome12q13.2
Protein FamilyInterleukin-6 family cytokine
Functionencodes a 189-amino acid protein that forms the p19 subunit of IL-23.
Primary Expressionvarious cell types:
Molecular Weight19 kDa
Amino Acids189 aa
Exons6
PathwaysNF-κB, TGF-β
UniProt IDQ9NPF7
NCBI Gene ID51561
Ensembl IDENSG00000110944
OMIM605502
GeneCardsIL23A
Human Protein AtlasIL23A
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsAND, ATF4, AUTOPHAGY, Chemokine, CLDN5, CXCL1
KG Connections107 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ATF4 Gene
gene · KG edge: activates
CLDN5 — Claudin-5
gene · KG edge: inhibits
CXCL1
gene · KG edge: activates
CXCL2 — C-X-C Motif Chemokine Ligand 2
gene · KG edge: activates

Knowledge Graph (12 edges)

CXCL2 inhibits IL23A
IL6 inhibits IL23A
ATF4 therapeutic_target IL23A
PPP1R15A therapeutic_target IL23A
IL12B inhibits IL23A
XBP1 therapeutic_target IL23A
CXCL1 inhibits IL23A
DDIT3 therapeutic_target IL23A
CLDN5 inhibits IL23A
HSPA5 therapeutic_target IL23A

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