PDGFR

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

PDGFR-Beta Protein

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graph TD
    PDGFR(["PDGFR"])
    style PDGFR fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    Glioblastoma["Glioblastoma"]
    PI3K(["PI3K"])
    glioblastoma["glioblastoma"]
    pericytes(["pericytes"])
    MAPK_signaling(("MAPK signaling"))
    PI3K_AKT_mTOR_signaling(("PI3K-AKT-mTOR signaling"))
    Alzheimer_s_disease["Alzheimer's disease"]
    neurodegeneration["neurodegeneration"]
    glymphatic_clearance(("glymphatic clearance"))
    Huntington_s_disease(["Huntington's disease"])
    blood_brain_barrier["blood-brain barrier"]
    ERK(["ERK"])
    MAPK["MAPK"]

    PDGFR -->|"associated_with"| Glioblastoma
    PDGFR -->|"activates"| PI3K
    PDGFR -->|"associated_with"| glioblastoma
    PDGFR -->|"expressed_in"| pericytes
    PDGFR -->|"participates_in"| MAPK_signaling
    PDGFR -->|"participates_in"| PI3K_AKT_mTOR_signaling
    PDGFR -->|"regulates"| PI3K
    PDGFR -->|"regulates"| Alzheimer_s_disease
    PDGFR -->|"protects_against"| neurodegeneration
    PDGFR -->|"participates_in"| glymphatic_clearance
    PDGFR -->|"associated_with"| Huntington_s_disease
    PDGFR -->|"participates_in"| blood_brain_barrier
    ERK -->|"activates"| PDGFR
    MAPK -->|"activates"| PDGFR

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class Glioblastoma disease
    class PI3K protein
    class glioblastoma disease
    class pericytes protein
    class MAPK_signaling pathway
    class PI3K_AKT_mTOR_signaling pathway
    class Alzheimer_s_disease disease
    class neurodegeneration disease
    class glymphatic_clearance pathway
    class Huntington_s_disease protein
    class blood_brain_barrier mechanism
    class ERK protein
    class MAPK gene