gene 842 words KG: GALC
Contents

GALC Gene

🧬 Gene Info
Gene SymbolGALC
Full NameGalactocerebrosidase
Chromosome14q31.3 (Chr14: 87,934,475-88,013,430)
FunctionGALC encodes galactocerebrosidase, a lysosomal hydrolase that catalyzes the hydrolysis of galactocerebroside, a major lipid component of myelin.
Primary Expressionbrain white matter, peripheral nerves
Molecular Weight80 kDa
PathwaysTgf-Β
UniProt IDP54803
NCBI Gene ID2581
Ensembl IDENSG00000135837
OMIM245000
GeneCardsGALC
Human Protein AtlasGALC
Associated DiseasesMs
InteractionsAUTOPHAGY, CANCER, CTSD, GLA, GPR37, LRRK2
KG Connections41 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68

Related Analyses (4)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Myelin Basic Protein (MBP) - Biomarker
biomarker · KG edge: causes
Microglia
cell · KG edge: causes
Microglia in Neurodegeneration
entity · KG edge: causes
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: causes
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: contributes_to

Knowledge Graph (12 edges)

GALC activates RAC1
GALC interacts_with PSAP
GALC activates GPR37
GALC activates SMAD4
GALC interacts_with CTSD
ARSA associated_with GALC
GLA associated_with GALC
GALC contributes_to PSAP
GFAP causes GALC
GALC causes PLP1

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