concept

DISEASE-ASSOCIATED MICROGLIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DISEASE-ASSOCIATED MICROGLIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

364Connections

8Hypotheses

0Analyses

50Outgoing

50Incoming

3Experiments

0Debates

Summary

DISEASE-ASSOCIATED MICROGLIA is a concept in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with Aging, Als, Alzheimer. Connected to 146 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DISEASE-ASSOCIATED MICROGLIA
Key Genes/Proteins	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Amyloid, Angiogenesis

Wiki Pages (1)

Knowledge base pages for this entity

Disease-Associated Microglia

cell · 1120 words

Pathway Diagram

graph TD
    DISEASE_ASSOCIATED_MICROGLIA["DISEASE-ASSOCIATED MICROGLIA"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"activates"| Ms["Ms"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"activates"| Tumor["Tumor"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Inflammation["Inflammation"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Alzheimer["Alzheimer"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Aging["Aging"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Tauopathy["Tauopathy"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Dementia["Dementia"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"target for"| Als["Als"]
    TREM2["TREM2"] -->|"regulates"| DISEASE_ASSOCIATED_MICROGLIA
    MICROGLIA["MICROGLIA"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    CYTOKINES["CYTOKINES"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    TNF["TNF"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    TNFR1["TNFR1"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    AGING["AGING"] -->|"expressed in"| DISEASE_ASSOCIATED_MICROGLIA
    BCL2["BCL2"] -->|"expressed in"| DISEASE_ASSOCIATED_MICROGLIA

Outgoing (245)

Target	Relation	Type	Str
Neurodegeneration	associated_with	disease	0.95
Alzheimer'S Disease	associated_with	disease	0.95
Neurodegeneration	activates	disease	0.95
Neuroprotective Signature	expressed_in	phenotype	0.90
Alzheimer's Disease	associated_with	disease	0.90
Pathological Phenotypes	contributes_to	phenotype	0.90
pro-inflammatory factors	upregulates	protein	0.90
Alzheimer's Disease	biomarker_for	disease	0.90
Microglial Subtypes	associated_with	cell_type	0.90
Central Nervous System Damage	mediates	process	0.90
Amyloid Beta	interacts_with	protein	0.90
Central Nervous System Damage	involved_in	process	0.90
TREM2	associated_with	gene	0.90
Multiple Sclerosis	associated_with	disease	0.90
Alzheimer'S	involved_in	disease	0.87
Neuroinflammation	promotes	process	0.85
Alzheimer's Disease	implicated_in	disease	0.85
Epilepsy	associated_with	disease	0.85
Microglia	associated_with	cell_type	0.85
Alzheimer	activates	disease	0.85
Alzheimer'S Disease Progression	modulates	process	0.85
Early Cns Damage Detection	involved_in	process	0.85
amyloid-beta	downregulates	compound	0.85
Autism Spectrum Disorder	associated_with	disease	0.85
Lewy Body Diseases	associated_with	disease	0.85
Neurodegeneration	protects_against	disease	0.85
Brain Protection	protects_against	process	0.85
Amyloid Pathology	regulates	process	0.85
Neurodegenerative Diseases	therapeutic_target	disease	0.80
Neurodegeneration	mediates	process	0.80
NEURODEGENERATIVE DISEASES	associated_with	disease	0.80
Neurodegeneration Therapeutic Target	therapeutic_target	mechanism	0.80
Neuroinflammation	contributes_to	process	0.80
MICROGLIA	activates	gene	0.80
MICROGLIA	associated_with	gene	0.80
Alzheimer	expressed_in	disease	0.75
Alzheimer	associated_with	disease	0.75
Inflammation	activates	disease	0.75
Aging	associated_with	disease	0.75
Neuroinflammation	activates	disease	0.75
Als	activates	disease	0.75
Neurodegeneration	associated_with	disease	0.75
Biomarker	biomarker_for	biomarker	0.75
Brain Aging	associated_with	phenotype	0.75
Brain Aging	biomarker_for	disease	0.75
Als	associated_with	disease	0.75
Alzheimer's disease	associated_with	disease	0.70
NEUROINFLAMMATION	activates	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
ALZHEIMER'S DISEASE	expressed_in	gene	0.70

Incoming (119)

Source	Relation	Type	Str
TREM2	involved_in	gene	0.95
TREM2	regulates	protein	0.90
GPNMB	expressed_in	gene	0.90
APOE	regulates	gene	0.90
Alzheimer's Disease	associated_with	disease	0.90
TREM2	regulates	gene	0.90
Alzheimer'S Disease	associated_with	disease	0.90
TREM2 Signaling Pathway	regulates	pathway	0.88
White Matter-Associated Microglia	co_expressed_with	cell_type	0.88
TYROBP	regulates	protein	0.85
Alzheimer'S Disease	causes	disease	0.85
TREM2	expressed_in	gene	0.85
White Matter-Associated Microglia	associated_with	cell_type	0.85
Microglia Checkpoint Molecules	downregulates	mechanism	0.85
TREM2	modulates	protein	0.80
NEURODEGENERATION	activates	gene	0.80
TREM2	activates	gene	0.80
TAU	activates	gene	0.80
CYTOKINES	activates	gene	0.70
TREM2	regulates	gene	0.70
AMYLOID	activates	gene	0.70
ALZHEIMER	activates	gene	0.70
TAU PATHOLOGY	activates	gene	0.70
NEURODEGENERATIVE DISEASES	associated_with	gene	0.70
TREM2	associated_with	gene	0.70
ALZHEIMER	expressed_in	gene	0.70
NEURODEGENERATION	associated_with	gene	0.70
MICROGLIA	targets	cell_type	0.65
TNF	associated_with	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
ASTROCYTES	causes	gene	0.60
LPL	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
GAS6	associated_with	gene	0.60
AND	expressed_in	gene	0.60
ERK1/2	activates	gene	0.60
COMPLEMENT	associated_with	gene	0.60
AXL	associated_with	gene	0.60
CD2AP	inhibits	gene	0.60
CANCER	causes	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
AND	activates	gene	0.60
TREM2	inhibits	gene	0.60
C1Q	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
SYNAPSE	inhibits	gene	0.60
HER2	associated_with	gene	0.60
NF-ΚB	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.847	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.779	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.776	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.770	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

Disease-Associated Microglia Metabolic Reprogramming	0.718	neurodegeneration	Cell type vulnerability in Alzheimers Di
TREM2 haploinsufficiency dysregulates microglial synaptic su	0.700	neurodegeneration	Synaptic pruning by microglia in neurode
Disease-Associated Microglia (DAM) Program Drives IBA1 Downr	0.571	neuroinflammation	What causes IBA1 low/negative microglia

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice	validation	Alzheimer's disease	0.900	0.00	5xFAD transgenic mice	proposed	N/A
Transcriptomic profiling and differential expression analysis	exploratory	Alzheimer's disease	0.900	0.00	1-month-old APP/PS1 mice cereb	proposed	N/A
bEV isolation and LPS quantification from human samples	clinical	Alzheimer's disease	0.800	0.00	human patients	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445]	Qin J, Ma S, Wang J, Huang S, Luan J, He	Cell death & disease	2026	0
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795]	Gao C, Liu B, Zhang R, Tian J, Xin H	Toxicology mechanisms and meth	2026	0
NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890]	Rao W, Huang Y, Li J, Chen Q, Sun J et a	J Stroke Cerebrovasc Dis	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496]	Che L, Zhu L, Zhou L, Zhou Y	Biochim Biophys Acta Rev Cance	2026	0
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570]	Chien Y, Xia R, Zhou D, Ai Y, Wu L et al	Hepatol Commun	2026	0
Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558]	Singh P, Rath SL	Journal of Alzheimer's disease	2026	0
Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334]	Song C, Wu X, Chen C, Shen B, He Y, Liu	Drug design, development and t	2026	0
Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914]	["Xin R", "Zhang J", "Zhang Y", "Dai M",	Free radical biology & medicin	2026	0
Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086]	Wang Y, Zhang W, Zhang M, Zhu Y, Wang W,	Tissue & cell	2026	0
Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362]	Xu J, Sun M, Wang C, Ju P, Guan XD, Xie	International journal of ophth	2026	0
Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Am [PMID:40442550]	Wongjaikam S, Siengdee P, Somnus A, Govi	Neurotoxicity research	2025	0
Acyl-CoA synthetase long-chain family member 4-A novel prognostic marker in cuta [PMID:41918944]	Paria S, Lapides R, Saravi B, Rajagopal	Frontiers in medicine	2025	0
Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzhei [PMID:40640358]	Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhan	Scientific reports	2025	0
Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathol [PMID:39510074]	["Zha Xu", "Liu Xicheng", "Wei Mengping"	Cell metabolism	2025	0
Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis [PMID:41394684]	Montesinos J, Yun TD, Salomón-Cruz ID, A	bioRxiv : the preprint server	2025	0
Danggui Shaoyao San ameliorates Alzheimer's disease by regulating lipid metaboli [PMID:40271063]	Gong K, Zhou S, Xiao L, Xu M, Zhou Y, Lu	Frontiers in pharmacology	2025	0
Single-cell spatial transcriptomics reveals distinct patterns of dysregulation i [PMID:39103533]	Johnston KG, Berackey BT, Tran KM, Gelbe	Molecular psychiatry	2025	0
Deferiprone in Alzheimer Disease: A Randomized Clinical Trial. [PMID:39495531]	Ayton S, Barton D, Brew B, Brodtmann A,	JAMA neurology	2025	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DISEASE-ASSOCIATED MICROGLIA in their description or question text

Disease-Associated Microglia Metabolic Reprogramming

Score: 0.718 · neurodegeneration · 2026-04-12

## Mechanistic Overview Disease-Associated Microglia Metabolic Reprogramming starts from the claim that modulating TREM2

TREM2 haploinsufficiency dysregulates microglial synaptic surveillance, switchin

Score: 0.700 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) functions as a criti

Disease-Associated Microglia (DAM) Program Drives IBA1 Downregulation

Score: 0.571 · neuroinflammation · 2026-04-21

## Mechanistic Overview Disease-Associated Microglia (DAM) Program Drives IBA1 Downregulation starts from the claim that