gene

DCTN5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DCTN5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

27Outgoing

17Incoming

0Experiments

0Debates

Summary

Dynactin Subunit 5 gene in neurodegeneration

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🧬 Gene Info

Gene Symbol	DCTN5
Chromosome	16p12.2
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Spinal Cord
Pathways	Mitophagy, Alpha-Synuclein
GeneCards	DCTN5
Human Protein Atlas	DCTN5
Associated Diseases	ALS, Neurodegeneration, Parkinson
Interactions	Alpha-Synuclein, DAPK1, DCAF17, H2AX, MITOPHAGY, P62
KG Connections	44 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DCTN5 Gene

gene · 778 words

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DCTN5 Protein

protein · 1113 words

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Pathway Diagram

graph TD
    DCTN5["DCTN5"]
    TREM2["TREM2"]
    DCTN5 -->|"associated with"| TREM2
    microglia["microglia"]
    DCTN5 -->|"expressed in"| microglia
    OxPC["OxPC"]
    DCTN5 -->|"associated with"| OxPC
    neurodegeneration["neurodegeneration"]
    DCTN5 -->|"associated with"| neurodegeneration
    STRRIDE["STRRIDE"]
    DCTN5 -->|"associated with"| STRRIDE
    DCTN5 -->|"implicated in"| neurodegeneration
    style DCTN5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
microglia	expressed_in	cell_type	0.80
OxPC	associated_with	chemical	0.80
TREM2	associated_with	gene	0.80
STRRIDE	associated_with	entity	0.70
Parkinson	inhibits	disease	0.65
Parkinson	causes	disease	0.65
ALS	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Als	inhibits	disease	0.65
P62	causes	gene	0.60
Alpha-Synuclein	causes	pathway	0.60
Mitophagy	causes	pathway	0.60
ALPHA-SYNUCLEIN	causes	gene	0.60
Alpha-Synuclein	inhibits	protein	0.60
Ras	inhibits	protein	0.60
PARKINSON'S DISEASE	causes	gene	0.60
Mitophagy	inhibits	pathway	0.60
DAPK1	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
DCAF17	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
H2AX	inhibits	gene	0.60
P62	inhibits	gene	0.60
SNCA	activates	gene	0.60
Spinal Cord	expressed_in	brain_region	0.55

Incoming (17)

Source	Relation	Type	Str
PARKINSON	inhibits	gene	0.60
H2AX	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
P62	inhibits	gene	0.60
NEURODEGENERATION	causes	gene	0.60
DNA	causes	gene	0.60
NEUROTOXICITY	causes	gene	0.60
PARKINSON	causes	gene	0.60
MITOPHAGY	causes	gene	0.60
DAPK1	activates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
H2AX	causes	gene	0.60
DCAF17	activates	gene	0.60
PINK1	causes	gene	0.60
SNCA	activates	gene	0.60
UBIQUITIN	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DCTN5 in their description or question text

No additional research found