| Gene Symbol | CSNK2A1 |
| Chromosome | 20p13 |
| Function | Catalytic activity: α and α' subunits provide kinase activity |
| Primary Expression | hippocampus, cortex, and cerebellum |
| Amino Acids | 350 aa |
| Exons | 10 |
| Pathways | Notch |
| Ensembl ID | ENSG00000101266 |
| GeneCards | CSNK2A1 |
| Human Protein Atlas | CSNK2A1 |
| Heterotetramer formation | Combines with regulatory β subunits (CSNK2B) to form α₂β₂ or αα'β₂ holoenzymes |
| Constitutive activity | Unlike most kinases, CK2 is constitutively active without requiring phosphorylation |
| Ubiquitous expression | High levels in brain, particularly in neurons |
| Ser202/Thr205 | AT8 epitope (also GSK3β, CDK5 targets) |
| Ser396/Ser404 | PHF-1 epitope |
| Associated Diseases | Als, Alzheimer, Alzheimer's Disease, Ms, Neurodegeneration, Parkinson |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, App, HNRNPA2B1, NEURODEGENERATION, TAU |
| KG Connections | 58 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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