gene 1,421 words KG: CR2
Contents

CR2 (Complement Receptor Type 2)

🧬 Gene Info
Gene SymbolCR2
Full NameComplement Receptor Type 2 (CD21)
AliasesComplement Receptor Type 2, CD21
Chromosome1q32
Protein TypeReceptor
Functionis a membrane glycoprotein that serves as a primary receptor for fragments of complement component C3, particularly C3d, C3dg, and iC3b.
Primary Expressionsome tissues
Amino Acids1458 aa
Exons25
UniProt IDP08578
NCBI Gene ID1380
Ensembl IDENSG00000117322
OMIM120650
GeneCardsCR2
Human Protein AtlasCR2
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Dementia, Ms, neurodegeneration
InteractionsAQP4, AQUAPORIN-4, ASTROCYTE, ASTROCYTES, C3, COMPLEMENT
KG Connections61 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Aquaporin-4 Polarization Rescue
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Complement C1q Subtype Switching
Score: 0.66
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (10)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (11)

Astrocytes
cell · KG edge: inhibits
Astrocytes
entity · KG edge: inhibits
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: inhibits
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: inhibits
AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates

Knowledge Graph (12 edges)

AQP4 inhibits CR2
CR2 inhibits AQP4
AQP4 activates CR2
CR2 associated_with TREM2
CR2 associated_with IL6
CR2 associated_with ZCWPW1
CR2 associated_with CTSH
CR2 associated_with PILRB
CR2 associated_with GBA
CR2 associated_with CR1

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