gene 2,253 words KG: CHMP3
Contents

CHMP3 — Charged Multivesicular Body Protein 3

🧬 Gene Info
Gene SymbolCHMP3
Full NameCharged Multivesicular Body Protein 3
Chromosome2p21
Functionis a core component of the Endosomal Sorting Complex Required for Transport-III (ESCRT-III)[@hanson2012].
Primary Expressionneurons and has been increasingly recognized for its critical role in maintaining neuronal protein homeostasis[@lee2019]
Molecular Weight24 kDa
Amino Acids222 aa
PathwaysApoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt IDQ9Y3E0
NCBI Gene ID25973
Ensembl IDENSG00000115159
OMIM609538
GeneCardsCHMP3
Human Protein AtlasCHMP3
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsCHMP2A, CHMP4B, CHMP6, DISC1, EIF4G1, ESCRT-III
KG Connections33 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

APOE-Dependent Autophagy Restoration
Score: 0.88
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
Lysosomal Membrane Repair Enhancement
Score: 0.54

Related Analyses (7)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (13)

Apoptosis in Neurodegeneration
entity · KG edge: regulates
NGF (Redirect)
redirect · KG edge: regulates
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: regulates
BAG1 Gene
gene · KG edge: regulates
DISC1 — Disrupted in Schizophrenia 1
gene · KG edge: activates

Knowledge Graph (12 edges)

NBN regulates CHMP3
SGK3 regulates CHMP3
TNF regulates CHMP3
SLC24A2 regulates CHMP3
DNAJC2 regulates CHMP3
CHMP3 regulates PDE4C
CHMP3 regulates BAG1
CHMP3 regulates VTI1B
CHMP3 activates EIF4G1
CHMP3 regulates NOX1

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