gene

CHRNA6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHRNA6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

10Outgoing

1Incoming

0Experiments

0Debates

Summary

CHRNA6 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, contributes to, implicated in. Associated with Autoimmune, Cancer, Depression. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CHRNA6
Full Name	Cholinergic Receptor Nicotinic Alpha Subunit 6
Chromosome	8p21
Function	CHRNA6 encodes the alpha-6 subunit of nicotinic receptors.
Primary Expression	the brain and play roles in cognitive function, attention, and motor control
UniProt ID	[P31415](https://www.uniprot.org/uniprotkb/P31415/entry)
GeneCards	CHRNA6
Human Protein Atlas	CHRNA6
Associated Diseases	Nicotine addiction, movement disorders
Interactions	CALB2, GFAP, RAB3B
KG Connections	11 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHRNA6 Gene

gene · 648 words

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Pathway Diagram

graph TD
    CHRNA6["CHRNA6"]
    Schizophrenia{"Schizophrenia"}
    CHRNA6 -->|"inhibits"| Schizophrenia
    Cancer{"Cancer"}
    CHRNA6 -->|"contributes to"| Cancer
    Depression{"Depression"}
    CHRNA6 -->|"inhibits"| Depression
    Ms{"Ms"}
    CHRNA6 -->|"inhibits"| Ms
    Autoimmune{"Autoimmune"}
    CHRNA6 -->|"contributes to"| Autoimmune
    CANCER["CANCER"]
    CHRNA6 -->|"contributes to"| CANCER
    CALB2["CALB2"]
    CHRNA6 -->|"inhibits"| CALB2
    RAB3B["RAB3B"]
    CHRNA6 -->|"inhibits"| RAB3B
    Epigenetic(["Epigenetic"])
    CHRNA6 -->|"inhibits"| Epigenetic
    Notch(["Notch"])
    CHRNA6 -->|"contributes to"| Notch
    neurodegeneration["neurodegeneration"]
    CHRNA6 -->|"implicated in"| neurodegeneration
    GFAP["GFAP"]
    GFAP -->|"inhibits"| CHRNA6
    style CHRNA6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Autoimmune	contributes_to	disease	0.65
Schizophrenia	inhibits	disease	0.65
Cancer	contributes_to	disease	0.65
Depression	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Notch	contributes_to	pathway	0.60
Epigenetic	inhibits	pathway	0.60
CANCER	contributes_to	gene	0.60
CALB2	inhibits	gene	0.60
RAB3B	inhibits	gene	0.60

Incoming (1)

Source	Relation	Type	Str
GFAP	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHRNA6 in their description or question text

No additional research found