AGER

AGER Protein

Score: 0.297 Price: $0.30 Undruggable Druggability Status: active Wiki: AGER Gene

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 AGER — PDB 3CJJ Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.23

Clinical Stage

Preclinical

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (10 compounds)

10 Preclinical

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade

Drug Pipeline (10 compounds)

10 Preclinical

Known Drugs:

CHEMBL2179074 (preclinical)

CHEMBL2205553 (preclinical)

CHEMBL2205552 (preclinical)

CHEMBL2205550 (preclinical)

CHEMBL2205549 (preclinical)

CHEMBL2205572 (preclinical)

CHEMBL2205569 (preclinical)

CHEMBL2205568 (preclinical)

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: Q15109

🧬 3D Protein Structure

🧬 AGER — PDB 3CJJ Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

Open full viewer

AlphaFold predicted structure available for Q15109

View AlphaFold Structure

Linked Hypotheses (1)

Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade0.613

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

associated with (6)

AGER→MICROVASCULAR_COMPLICATIONSHSPA1B→AGERAGER→HSPA1AHSPA1A→AGERAGER→HSPA1B

▸ Show 1 more

AGER→neurodegeneration

binds to (2)

AGER→HSPA1AAGER→HSPA1B

co discussed (6)

TDC→AGERTLR4→AGERDDC→AGERGPR109A→AGERCHRNA7→AGER

▸ Show 1 more

AGER→CSGA

Debate History (0)

No debates yet