| Gene Symbol | AGERPROTEIN |
| Full Name | AGER/RAGE |
| Chromosome | 6p21.3 |
| Protein Type | Protein |
| Target Class | Protein |
| Function | is a pattern recognition receptor that plays a central role in linking metabolic stress, oxidative damage, and neuroinflammation in neurodegenerative diseases[@schmidt2000]. |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade |
| Primary Expression | various cell types within the central nervous system, including neurons, astrocytes, microglia, and vascular endothelial cells, where it mediates resp |
| Druggability | Undruggable (0.23) |
| UniProt ID | Search UniProt |
| GeneCards | AGERPROTEIN |
| Human Protein Atlas | AGERPROTEIN |
| Associated Diseases | AD, ALI, als, Alzheimer's disease |
| Known Drugs/Compounds | CHEMBL2179074, CHEMBL2205553, CHEMBL2205552, CHEMBL2205550, CHEMBL2205549, CHEMBL2205572 |
| Interactions | EGFR, HER2, HLA, HSPA1A, HSPA1B, NCOA4 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Blocking AGE-RAGE Signaling in Enteric Glia to Pre |
| KG Connections | 145 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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