Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GLO1 encodes glyoxalase 1, a key enzyme in methylglyoxal detoxification that protects neurons from advanced glycation end products and oxidative stress in neurodegenerative diseases.
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| Gene Symbol | GLO1 |
| Full Name | Glyoxalase 1 |
| Chromosome | 6p25.2 |
| Protein Type | Enzyme |
| Function | encodes a pivotal enzyme in the cellular defense against carbonyl stress and advanced glycation end product (AGE) formation. |
| Molecular Weight | 21 kDa |
| Amino Acids | 183 aa |
| Exons | 9 |
| UniProt ID | Q04760 |
| NCBI Gene ID | 2739 |
| Ensembl ID | ENSG00000124767 |
| OMIM | 138750 |
| GeneCards | GLO1 |
| Human Protein Atlas | GLO1 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GLO1["GLO1"]
neurodegeneration["neurodegeneration"]
GLO1 -->|"implicated_in"| neurodegeneration
style GLO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| AGER | associated_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GLO1 in their description or question text
No additional research found