concept

SOD1G93A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD1G93A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

0Hypotheses

1Analyses

14Outgoing

18Incoming

0Experiments

1Debates

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💡 Concept Info

Name	SOD1G93A
Key Genes/Proteins	AGER, CSF1R, RAGE, RNA, SOD1
Related Diseases	ALS, Alzheimer's disease, neuroinflammation
Related Pathways	ALOX15 upregulation, apoptosis pathway, glutamate signaling, NF-κB

Pathway Diagram

graph TD
    SOD1G93A[SOD1G93A]
    SOD1G93A -->|upregulates| Oxidative_Stress[Oxidative Stress]
    SOD1G93A -->|activates| NF__B[NF-κB]
    SOD1G93A -->|activates| neuroinflammation[neuroinflammation]
    SOD1G93A -->|participates in| glutamate_signaling[glutamate signaling]
    SOD1G93A -->|expressed in| Alzheimer_s_disease[Alzheimer's disease]
    SOD1G93A -->|participates in| apoptosis_pathway[apoptosis pathway]
    SOD1G93A -->|expressed in| stem_cells[stem cells]
    AGER[AGER] -->|expressed in| SOD1G93A
    RAGE[RAGE] -->|expressed in| SOD1G93A
    SOD1[SOD1] -.protects against.-> SOD1G93A
    CSF1R[CSF1R] -->|activates| SOD1G93A
    ALS[ALS] -->|expressed in| SOD1G93A

Outgoing (14)

Target	Relation	Type	Str
ALS	associated_with	disease	0.90
Oxidative Stress	upregulates	process	0.85
NF-κB	activates	pathway	0.80
neuroinflammation	activates	disease	0.70
ALOX15 upregulation	causes	mechanism	0.70
glutamate signaling	participates_in	pathway	0.60
neuroinflammation	inhibits	disease	0.60
Alzheimer's disease	expressed_in	disease	0.60
apoptosis pathway	participates_in	pathway	0.60
Alzheimer's disease	inhibits	disease	0.60
stem cells	expressed_in	cell_type	0.60
neuroinflammation	expressed_in	disease	0.60
microglia	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55

Incoming (18)

Source	Relation	Type	Str
SOD1	activates	gene	0.60
CSF1R	activates	gene	0.60
ALS	protects_against	gene	0.60
SOD1	protects_against	gene	0.60
ALS	associated_with	gene	0.60
ALS	expressed_in	gene	0.60
ALS	activates	gene	0.60
ALS	inhibits	gene	0.60
ALS	interacts_with	gene	0.60
RNA	expressed_in	gene	0.60
AGER	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
AGER	protects_against	gene	0.60
RAGE	implicated_in	gene	0.60
SOD1	associated_with	gene	0.60
SOD1	expressed_in	gene	0.60
AGER	associated_with	gene	0.50
AGER	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.680

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

closed · Rounds: 5 · Score: 0.59 · 2026-04-16

Related Research

Hypotheses and analyses mentioning SOD1G93A in their description or question text

No additional research found