| Gene Symbol | AGER |
| Full Name | RAGE |
| Chromosome | 6p21.3 |
| Protein Type | Receptor |
| Target Class | Protein |
| Function | RAGE is a multi-ligand receptor that binds: - Advanced glycation end products (AGEs) - HMGB1 (High Mobility Group Box 1) - S100B protein - Amyloid-beta fibrils - DNA release from damaged cells |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade |
| Druggability | Undruggable (0.23) |
| Pathways | NF-κB, MAPK |
| UniProt ID | Q15120 |
| NCBI Gene ID | 177 |
| OMIM | 600841 |
| GeneCards | AGER |
| Human Protein Atlas | AGER |
| Associated Diseases | AD, ALI, als, Alzheimer's disease |
| Known Drugs/Compounds | CHEMBL2179074, CHEMBL2205553, CHEMBL2205552, CHEMBL2205550, CHEMBL2205549, CHEMBL2205572 |
| Interactions | EGFR, HER2, HLA, HSPA1A, HSPA1B, NCOA4 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Blocking AGE-RAGE Signaling in Enteric Glia to Pre |
| KG Connections | 144 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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