Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about dll3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DLL3 |
| Full Name | Delta-Like 3 |
| Chromosome | 19q13.2 |
| Function | encodes a type I transmembrane protein of 667 amino acids with a molecular weight of approximately 75 kDa. |
| Primary Expression | the developing nervous system |
| Molecular Weight | 75 kDa |
| Amino Acids | 667 aa |
| Exons | 8 |
| Pathways | Notch, notch, Notch pathway, Notch signaling |
| UniProt ID | [Q9NZU6](https://www.uniprot.org/uniprot/Q9NZU6) |
| Ensembl ID | ENSG00000090932 |
| GeneCards | DLL3 |
| Human Protein Atlas | DLL3 |
| Notch1 | Primary receptor for DLL3 |
| Notch2 | Secondary receptor |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DLL3["DLL3"]
DLL3 -.biomarker for.-> Tumor["Tumor"]
DLL3 -->|"target for"| Cancer["Cancer"]
DLL3 -->|"target for"| Aging["Aging"]
DLL3 -->|"target for"| Lung_Cancer["Lung Cancer"]
DLL3 -.biomarker for.-> Neurogenesis["Neurogenesis"]
DLL3 -->|"expressed in"| Akt["Akt"]
DLL3 -->|"expressed in"| Notch["Notch"]
DLL3 -.biomarker for.-> Angiogenesis["Angiogenesis"]
AKT["AKT"] -->|"expressed in"| DLL3
PTEN["PTEN"] -->|"expressed in"| DLL3| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:DLL3 | data_in | dataset_row | 0.00 |
| Lung Cancer | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Tumor | biomarker_for | disease | 0.65 |
| Neurogenesis | biomarker_for | pathway | 0.60 |
| Akt | expressed_in | pathway | 0.60 |
| Notch | expressed_in | pathway | 0.60 |
| NEUROTOXICITY | therapeutic_target | gene | 0.60 |
| Angiogenesis | biomarker_for | pathway | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| Differentiation | therapeutic_target | pathway | 0.60 |
| Immunotherapy | therapeutic_target | pathway | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:DLL3 | data_in | dataset_row | 0.00 |
| AKT | expressed_in | gene | 0.60 |
| PTEN | expressed_in | gene | 0.60 |
| AGER | therapeutic_target | gene | 0.50 |
| AGER | associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning dll3 in their description or question text
No additional research found