Closed-loop transcranial alternating current stimulation to restore hippocampal-prefrontal gamma synchrony via PV interneuron rescue

h-var-d749cd28cb

## Mechanistic Overview Closed-loop transcranial alternating current stimulation to restore hippocampal-prefrontal gamma synchrony via PV interneuron rescue starts from the claim that modulating SST within the disease context of Alzheimer's disease can redirect a disease-relevant process. The original description reads: "## Mechanistic Overview Closed-loop transcranial alternating current stimulat

Elo ratings (across arenas)

Arena	Rating	RD	W-L-D	N
global	1650	±129	6-4-0	10
loop:loop-74f20cb27aad	1540	±233	1-1-1	3
alzheimers	1350	±141	3-6-0	9

Ancestry (oldest → this)

mutate · gen 1

parent: h-bdbd2120

Descendants

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

2229 (55 matches)

mutate Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

2005 (54 matches)

mutate Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

1533 (23 matches)

crossover Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

1630 (44 matches)

crossover Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

1449 (11 matches)

mutate Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening

1366 (4 matches)

mutate Optogenetic restoration of hippocampal gamma oscillations via selective SST inte

1511 (4 matches)

crossover Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

1228 (3 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1345 (3 matches)

crossover Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to resto

1872 (19 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1501 (4 matches)

crossover Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

1613 (16 matches)

crossover APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma Oscillation Restorati

1500 (0 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1500 (0 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1500 (0 matches)

crossover Closed-loop transcranial focused ultrasound with real-time gamma feedback to res

1208 (2 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1208 (2 matches)

crossover Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons

1208 (2 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

crossover Real-time closed-loop transcranial focused ultrasound targeting PV interneurons

mutate Optogenetic restoration of hippocampal gamma oscillations via channelrhodopsin-2

1500 (0 matches)

crossover Real-time closed-loop transcranial focused ultrasound targeting PVALB interneuro

1500 (0 matches)

crossover Closed-loop transcranial focused ultrasound with adaptive API-guided targeting t

mutate Optogenetic restoration of SST interneuron-mediated dendritic inhibition to resc

mutate Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

1404 (6 matches)

mutate Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

1823 (52 matches)

mutate Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

1883 (53 matches)

mutate Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

2127 (55 matches)

mutate Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic inhibiti

1319 (4 matches)

mutate Closed-loop tACS targeting EC-II somatostatin interneurons to restore dendritic

1208 (2 matches)

mutate Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

1515 (8 matches)

mutate Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-ga

1701 (24 matches)

mutate Closed-loop optogenetic targeting PV interneurons to restore theta-gamma couplin

1547 (16 matches)

mutate Real-time optogenetic activation of CA3 PV interneurons to restore theta-gamma c

1500 (0 matches)

crossover Closed-loop tFUS targeting of EC-II SST interneurons to prevent ACSL4-mediated f

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