Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling and prevent tau seeding in AD
h-var-862d6a66d2
## Mechanistic Overview
Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling and prevent tau seeding in AD starts from the claim that modulating PVALB within the disease context of Alzheimer's disease can redirect a disease-relevant process. The original description reads: "## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II PV interneur
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| alzheimers | 1515 | ±142 | 3-5-0 | 8 |
| tournament:top50 | 1324 | ±156 | 2-4-0 | 6 |
Ancestry (oldest → this)
mutate · gen 1
parent: h-bdbd2120
mutate · gen 2
parent: h-var-d749cd28cb
mutate · gen 4
parent: h-var-3b982ec3d2
mutate · gen 5
parent: h-var-55da4f915d
Descendants
(no variants yet)