Gamma entrainment therapy to restore hippocampal-cortical synchrony

h-bdbd2120

## Mechanistic Overview Gamma entrainment therapy to restore hippocampal-cortical synchrony starts from the claim that modulating SST within the disease context of Alzheimer's disease can redirect a disease-relevant process. The original description reads: "**Gamma Entrainment Therapy for Alzheimer's Disease: Circuit-Level Intervention** **Overview and Neurophysiological Basis** Gamma oscillations

Elo ratings (across arenas)

Arena	Rating	RD	W-L-D	N
alzheimers	1900	±69	35-19-0	54
global	1673	±143	6-4-0	10
alzheimers-demo	1623	±217	2-1-0	3
loop:loop-228321644dbc	1500	±350	0-0-0	0
loop:loop-74f20cb27aad	1497	±256	1-1-0	2
test-alzheimers	1338	±290	0-1-0	1
tournament:top50	1333	±184	0-4-0	4

Ancestry (oldest → this)

(no parents — root hypothesis)

Descendants

crossover 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively

1496 (23 matches)

mutate Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling f

1791 (55 matches)

mutate Closed-loop transcranial alternating current stimulation to restore hippocampal-

1650 (10 matches)

crossover Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to resto

1872 (19 matches)

mutate Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical mem

1371 (3 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

2229 (55 matches)

mutate Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

2005 (54 matches)

mutate Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

1533 (23 matches)

crossover Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

1630 (44 matches)

crossover Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

1449 (11 matches)

mutate Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening

1366 (4 matches)

mutate Optogenetic restoration of hippocampal gamma oscillations via selective SST inte

1511 (4 matches)

crossover Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

1228 (3 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1345 (3 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1501 (4 matches)

crossover Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

1613 (16 matches)

crossover APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma Oscillation Restorati

1500 (0 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1500 (0 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1500 (0 matches)

crossover Closed-loop transcranial focused ultrasound with real-time gamma feedback to res

1208 (2 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

1208 (2 matches)

crossover Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons

1208 (2 matches)

mutate Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

crossover Real-time closed-loop transcranial focused ultrasound targeting PV interneurons

mutate Optogenetic restoration of hippocampal gamma oscillations via channelrhodopsin-2

1500 (0 matches)

crossover Real-time closed-loop transcranial focused ultrasound targeting PVALB interneuro

1500 (0 matches)

crossover Closed-loop transcranial focused ultrasound with adaptive API-guided targeting t

mutate Optogenetic restoration of SST interneuron-mediated dendritic inhibition to resc

mutate Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

1404 (6 matches)

mutate Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

1823 (52 matches)

mutate Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

1883 (53 matches)

mutate Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

2127 (55 matches)

mutate Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic inhibiti

1319 (4 matches)