Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent amyloid-induced synaptic dysfunction in AD

h-var-e95d2d1d86

## Mechanistic Overview Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent amyloid-induced synaptic dysfunction in AD starts from the claim that modulating PVALB within the disease context of Alzheimer's disease can redirect a disease-relevant process. The original description reads: "## **Molecular Mechanism and Rationale** The therapeutic strategy cente