Closed-loop tFUS targeting of EC-II SST interneurons to prevent ACSL4-mediated ferroptotic priming in disease-associated microglia

h-var-be3485f0c9

Somatostatin-positive interneurons in entorhinal cortex layer II serve dual roles as gamma frequency gatekeepers and microglial modulators through SST-mediated signaling. During Alzheimer's disease progression, loss of SST interneuron function contributes to both gamma oscillation deficits and pathological microglial activation. This hypothesis proposes that closed-loop focused ultrasound targetin