Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD
h-var-14d7585dd1
## Mechanistic Overview
Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD starts from the claim that modulating PVALB within the disease context of Alzheimer's disease can redirect a disease-relevant process. The original description reads: "## Mechanistic Overview Closed-loop tACS targeting EC-II PV interneurons to suppres
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| alzheimers | 1866 | ±69 | 31-23-0 | 54 |
| global | 1680 | ±129 | 9-3-0 | 12 |
| loop:loop-74f20cb27aad | 1645 | ±302 | 0-0-1 | 1 |
| tournament:top50 | 1346 | ±154 | 0-6-0 | 6 |
Ancestry (oldest → this)
mutate · gen 1
parent: h-bdbd2120
mutate · gen 2
parent: h-var-d749cd28cb
mutate · gen 4
parent: h-var-3b982ec3d2
Descendants
(no variants yet)