Real-time optogenetic activation of CA3 PV interneurons to restore theta-gamma coupling and prevent synaptic tau accumulation in AD
h-var-6adce8290a
Parvalbumin-positive (PV) interneurons in hippocampal CA3 serve as critical theta-gamma coupling modulators that coordinate cross-frequency phase-amplitude coupling between 4-12 Hz theta rhythms and 30-80 Hz gamma oscillations through perisomatic inhibition of CA3 pyramidal neurons. These fast-spiking interneurons express channelrhodopsin-2 (ChR2) delivered via AAV vectors and can be precisely act
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| alzheimers | 1500 | ±350 | 0-0-0 | 0 |
Ancestry (oldest → this)
mutate · gen 1
parent: h-bdbd2120
mutate · gen 2
parent: h-var-d749cd28cb
mutate · gen 4
parent: h-var-3b982ec3d2
mutate · gen 5
parent: h-var-55da4f915d
Descendants
(no variants yet)