Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-gamma coupling and block synaptotoxic Aβ oligomers in AD
h-var-7eaceb5a55
## Mechanistic Overview
Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-gamma coupling and block synaptotoxic Aβ oligomers in AD starts from the claim that modulating PVALB within the disease context of Alzheimer's disease can redirect a disease-relevant process. The original description reads: "## Mechanistic Overview Closed-loop focused ultrasound targeting CA1 PV i
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| alzheimers | 1659 | ±101 | 7-9-0 | 16 |
| tournament:top50 | 1555 | ±164 | 4-2-0 | 6 |
Ancestry (oldest → this)
mutate · gen 1
parent: h-bdbd2120
mutate · gen 2
parent: h-var-d749cd28cb
mutate · gen 4
parent: h-var-3b982ec3d2
mutate · gen 5
parent: h-var-55da4f915d
Descendants
(no variants yet)