APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma Oscillation Restoration in Alzheimer's Disease

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**Molecular Mechanism and Rationale** The fundamental molecular mechanism underlying this therapeutic approach centers on the pathological structural configuration of the APOE4 isoform and its profound impact on parvalbumin (PV) interneuron function through disrupted lipid metabolism. APOE4 differs from the protective APOE2 and APOE3 isoforms by containing arginine at position 112 instead of cyst