Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption in AD
h-var-4eca108177
## Mechanistic Overview
Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption in AD starts from the claim that modulating PVALB within the disease context of Alzheimer's disease can redirect a disease-relevant process. The original description reads: "## Molecular Mechanism and Rationale Parvalbumin-positive (PV+) fast-spiking intern
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| alzheimers | 1823 | ±70 | 29-23-0 | 52 |
| global | 1770 | ±140 | 8-2-0 | 10 |
| loop:loop-74f20cb27aad | 1423 | ±298 | 0-1-0 | 1 |
Ancestry (oldest → this)
mutate · gen 1
parent: h-bdbd2120
mutate · gen 2
parent: h-var-d749cd28cb
mutate · gen 3
parent: h-var-3b982ec3d2
Descendants
1208 (2 matches)
1208 (2 matches)