Closed-loop transcranial focused ultrasound with adaptive API-guided targeting to restore hippocampal gamma oscillations via PV interneuron recruitment in Alzheimer's disease

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This hypothesis combines closed-loop transcranial focused ultrasound (tFUS) with real-time API-guided adaptive targeting to restore hippocampal gamma oscillations in Alzheimer's disease through precise PV interneuron recruitment. The approach leverages API verification protocols to dynamically optimize ultrasound parameters based on real-time EEG gamma power monitoring and individual patient respo