Optogenetic restoration of SST interneuron-mediated dendritic inhibition to rescue hippocampal gamma oscillations in early Alzheimer's disease

h-var-7586582905

This intervention targets somatostatin-positive (SST) interneurons in the CA1 stratum oriens and radiatum to restore gamma oscillations through dendritic inhibition rather than perisomatic control. While parvalbumin interneurons provide perisomatic inhibition that shapes gamma timing, SST interneurons deliver dendritic inhibition that modulates gamma power and propagation throughout the hippocampa