protein

UFD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UFD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

15Outgoing

13Incoming

0Experiments

0Debates

Summary

UFD1 protein - VCP cofactor, ERAD, ALS/FTD, protein quality control

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🔬 Protein Info

Gene Symbol	UFD1
Aliases	UFD1 protein
Function	UFD1 (ubiquitin fusion degradation protein 1) is a cofactor for VCP/p97 (valosin-containing protein), forming the UFD1-NPL4 complex that recognizes ubiquitinated substrates for VCP-mediated extract...
Molecular Weight	36.7 kDa
Pathways	ubiquitin-proteasome, autophagy pathway
GeneCards	UFD1
Human Protein Atlas	UFD1
Associated Diseases	ALS, dementia, frontotemporal
Interactions	ATG14, LC3B, MAP1LC3B, NPL4, PIK3C3, RPL26
KG Connections	28 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

UFD1 Protein

protein · 670 words

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Pathway Diagram

graph TD
    UFD1(["UFD1"])
    style UFD1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    VCP["VCP"]
    ubiquitin_proteasome(("ubiquitin-proteasome"))
    autophagy_pathway(("autophagy pathway"))
    NPL4(["NPL4"])
    UBXD1["UBXD1"]

    UFD1 -->|"interacts_with"| VCP
    UFD1 -->|"participates_in"| ubiquitin_proteasome
    UFD1 -->|"participates_in"| autophagy_pathway
    NPL4 -->|"interacts_with"| UFD1
    UBXD1 -->|"interacts_with"| UFD1

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class VCP gene
    class ubiquitin_proteasome pathway
    class autophagy_pathway pathway
    class NPL4 protein
    class UBXD1 gene

Outgoing (15)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.60
ALS	activates	disease	0.60
frontotemporal dementia	activates	disease	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
UFL1	activates	gene	0.60
UFM1	activates	gene	0.60
UVRAG	activates	gene	0.60
VCP	activates	gene	0.60
VCP	interacts_with	gene	0.55
ubiquitin-proteasome	participates_in	pathway	0.55
autophagy pathway	participates_in	pathway	0.55
UFM1	co_expressed_with	gene	0.50
UFL1	co_expressed_with	protein	0.50

Incoming (13)

Source	Relation	Type	Str
SQSTM1	activates	gene	0.60
RPL26	activates	gene	0.60
RPN1	activates	gene	0.60
ATG14	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
NPL4	activates	gene	0.60
PIK3C3	activates	gene	0.60
SYK	interacts_with	gene	0.60
UBXD1	interacts_with	gene	0.55
NPL4	interacts_with	gene	0.55
RPN1	co_expressed_with	gene	0.50
SQSTM1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UFD1 in their description or question text

No additional research found