Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UBXD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive page on UBXD1, a UBX domain-containing protein involved in ER-associated degradation, VCP/p97 regulation, and protein quality control relevant to neurodegeneration.
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| Gene Symbol | UBXD1 |
| Chromosome | 19p13.3 |
| Protein Family | UBX Domain Family, UBXN Family |
| Function | ER-Associated Degradation (ERAD): UBXD1 recruits ubiquitinated substrates to the p97 ATPase complex for extraction from the ER membrane into the cytosol, where they are degraded by the 26S proteasome[ |
| Primary Expression | human tissues, with high expression in brain (particularly neurons), heart, and liver |
| Subcellular Localization | Endoplasmic Reticulum, Cytoplasm, Nucleus |
| Molecular Weight | 43 kDa |
| Amino Acids | 377 aa |
| Exons | 9 |
| Pathways | autophagy pathway, ubiquitin-proteasome |
| UniProt ID | Q9Y5J7 |
| GeneCards | UBXD1 |
| Human Protein Atlas | UBXD1 |
| Brain | High expression in neurons throughout the brain, with particular abundance in regions vulnerable to neurodegeneration. |
| Spinal Cord | Significant expression in motor neurons, the cell type affected in ALS. |
| Associated Diseases | neurodegeneration |
| Interactions | NPL4, UFD1, VCP |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["UBXD1
UBX Domain Protein 1"]
B["VCP
Valosin Containing Protein"]
C["Protein Quality Control"]
D["ERAD Pathway
ER-Associated Degradation"]
E["Autophagy"]
F["Proteasomal Degradation"]
G["Misfolded Proteins"]
H["ER Stress"]
I["Mitochondrial Dysfunction"]
J["Neuronal Cell Death"]
K["Neurodegeneration"]
L["ALS/FTD"]
M["Inclusion Body Myopathy"]
N["TDP-43 Pathology"]
O["Tau Pathology"]
A -->|"binds to"| B
B -->|"regulates"| C
C -->|"activates"| D
C -->|"activates"| E
C -->|"activates"| F
G -->|"triggers"| H
H -->|"impairs"| C
F -->|"degrades"| G
E -->|"clears"| G
B -->|"dysfunction leads to"| I
I -->|"promotes"| J
J -->|"causes"| K
K -->|"manifests as"| L
K -->|"manifests as"| M
G -->|"forms"| N
G -->|"forms"| O
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff
class A central
class C,D,E,F protective
class G,H,I,J,K,N,O pathological
class B regulatory
class L,M disease| Target | Relation | Type | Str |
|---|---|---|---|
| VCP | regulates | gene | 0.60 |
| UFD1 | interacts_with | gene | 0.55 |
| ubiquitin-proteasome | participates_in | pathway | 0.55 |
| autophagy pathway | participates_in | pathway | 0.55 |
| VCP | binds_to | gene | 0.55 |
| VCP | interacts_with | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning UBXD1 in their description or question text
No additional research found