concept

TRIB3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

24Outgoing

12Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TRIB3
Key Genes/Proteins	AKT, AND, APOPTOSIS, ATF4, AUTOPHAGY, CANCER
Related Diseases	Als, Cancer, Cirrhosis, Fibrosis
Related Pathways	Akt, Apoptosis, Autophagy, Er Stress

Pathway Diagram

graph TD
    TRIB3["TRIB3"]
    TRIB3 -->|"regulates"| FOXM1["FOXM1"]
    TRIB3 -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    TRIB3 -->|"activates"| Tumor["Tumor"]
    TRIB3 -->|"activates"| Glioma["Glioma"]
    TRIB3 -->|"activates"| Als["Als"]
    TRIB3 -->|"activates"| Cirrhosis["Cirrhosis"]
    TRIB3 -->|"activates"| Fibrosis["Fibrosis"]
    TRIB3 -->|"inhibits"| Cancer["Cancer"]
    MITOPHAGY["MITOPHAGY"] -->|"activates"| TRIB3
    ATF4["ATF4"] -->|"activates"| TRIB3
    DDIT3["DDIT3"] -->|"activates"| TRIB3
    AKT["AKT"] -->|"activates"| TRIB3
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| TRIB3
    TRPV4["TRPV4"] -->|"activates"| TRIB3
    AND["AND"] -->|"activates"| TRIB3

Outgoing (24)

Target	Relation	Type	Str
Fibrosis	activates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Cirrhosis	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Glioma	activates	disease	0.65
MTOR	activates	gene	0.60
Mtor	activates	pathway	0.60
Er Stress	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
Akt	activates	pathway	0.60
P62	expressed_in	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
Autophagy	inhibits	pathway	0.60
FOXO3	inhibits	gene	0.60
FOXM1	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
ATF4	activates	gene	0.60
Apoptosis	inhibits	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
TRPV4	activates	gene	0.60
AKT	activates	gene	0.60

Incoming (12)

Source	Relation	Type	Str
SMAD3	activates	gene	0.60
TGF	activates	gene	0.60
AND	inhibits	gene	0.60
SQSTM1	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
MITOPHAGY	activates	gene	0.60
ATF4	activates	gene	0.60
DDIT3	activates	gene	0.60
AKT	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
TRPV4	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRIB3 in their description or question text

No additional research found