concept

TRIAD3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIAD3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

50Outgoing

19Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TRIAD3A
Key Genes/Proteins	Actin, ALZHEIMER, ALZHEIMER DISEASE, AMPK, AMYLOID, AND
Related Diseases	Alzheimer, Alzheimer's disease
Related Pathways	Amyloid, Apoptosis, autophagy pathway

Pathway Diagram

graph TD
    TRIAD3A["TRIAD3A"]
    TRIAD3A -->|"involved_in"| Autophagy["Autophagy"]
    TRIAD3A -->|"mediates"| Liquid_Liquid_Phase_Separation["Liquid-Liquid Phase Separation"]
    TRIAD3A -->|"downregulates"| Phosphorylated_Tau["Phosphorylated Tau"]
    TRIAD3A -->|"binds"| LC3["LC3"]
    TRIAD3A -.protects against.-> Tauopathy["Tauopathy"]
    TRIAD3A -->|"co_expressed_with"| Tau_Amyloid["Tau Amyloid"]
    TRIAD3A -->|"interacts"| Alzheimer["Alzheimer"]
    TAU["TAU"] -->|"activates"| TRIAD3A
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"interacts"| TRIAD3A
    LC3 -->|"interacts"| TRIAD3A
    TAUOPATHY["TAUOPATHY"] -->|"activates"| TRIAD3A
    NEURODEGENERATION["NEURODEGENERATION"] -->|"causes"| TRIAD3A
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| TRIAD3A
    AMPK["AMPK"] -->|"regulates"| TRIAD3A
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| TRIAD3A

Outgoing (53)

Target	Relation	Type	Str
Tau	associated_with	protein	0.95
Autophagy	involved_in	process	0.95
Tau Fibrillation	associated_with	process	0.95
Liquid-Liquid Phase Separation	mediates	process	0.93
Phosphorylated Tau	downregulates	biomarker	0.92
TAU	promotes_aggregation_of	protein	0.90
LC3	regulates	gene	0.90
Tauopathy	protects_against	disease	0.90
LC3	binds	gene	0.90
TAU	promotes fibrillation of	protein	0.90
Tau Amyloid	co_expressed_with	biomarker	0.85
TAU	promotes	protein	0.80
Neurodegeneration	causes	disease	0.65
Fibrosis	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cardiomyopathy	therapeutic_target	disease	0.65
Cardiac	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Tauopathy	activates	disease	0.65
Ms	interacts_with	disease	0.65
App	associated_with	protein	0.60
TAU	activates	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
Autophagy	activates	pathway	0.60
LC3	degrades	gene	0.60
Rb	activates	protein	0.60
AUTOPHAGY	activates	gene	0.60
LC3	interacts_with	gene	0.60
Ubiquitin	degrades	protein	0.60
ALZHEIMER	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
Amyloid	interacts_with	pathway	0.60
Actin	degrades	protein	0.60
NEURODEGENERATION	causes	gene	0.60
TLR9	degrades	gene	0.60
APOPTOSIS	regulates	gene	0.60
Cardiomyocyte	regulates	cell_type	0.60
Insulin	regulates	protein	0.60
autophagy pathway	participates_in	pathway	0.60
neurodegeneration	causes	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Alzheimer's disease	expressed_in	disease	0.60
TLR9	regulates	gene	0.60
neurodegeneration	associated_with	disease	0.60
Oxidative Stress	regulates	pathway	0.60
Lipid Metabolism	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Toll-Like Receptor	regulates	pathway	0.60

Incoming (19)

Source	Relation	Type	Str
TAU	interacts_with	protein	0.90
NEURODEGENERATION	causes	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
LC3	degrades	gene	0.60
RNF216	causes	gene	0.60
AND	regulates	gene	0.60
TAU	activates	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
TAUOPATHY	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
AMPK	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
PGC1A	regulates	gene	0.60
AMYLOID	interacts_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRIAD3A in their description or question text

No additional research found