Contents

RAGE (Receptor for Advanced Glycation End Products)

🔬 Protein Info

Gene Symbol	RAGE
Aliases	Receptor for Advanced Glycation End Products
Protein Type	Receptor
Function	In the healthy nervous system, RAGE participates in: - Development: Neuronal differentiation and migration during embryonic development - Repair: Tissue repair and regeneration following injury - Infl
Primary Expression	hippocampus, cortex, spinal cord, Thalamus, Hypothalamus
Subcellular Localization	</th><td>Cell surface (membrane), cytoplasm, nucleus</td></tr>
Molecular Weight	45 kDa
Pathways	NF-κB, MAPK pathway, NF-κB signaling
GeneCards	RAGE
Human Protein Atlas	RAGE
Extracellular domain	One V-type immunoglobulin domain (responsible for ligand binding) and two C-type domains
Transmembrane domain	Single-pass transmembrane helix
Intracellular domain	Cytoplasmic tail required for signal transduction
Development	Neuronal differentiation and migration during embryonic development
Repair	Tissue repair and regeneration following injury
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, cancer
Known Drugs/Compounds	metformin, RAPAMYCIN, resveratrol, RESVERATROL
Interactions	ABCA1, ACHE, AD, ADAM10, AGER, AGING
KG Connections	1335 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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Knowledge Graph

TLR2 interacts_with RAGE

CD36 associated_with RAGE

CMKLR1 activates RAGE

RAGE interacts_with CD14

HMGB1 activates RAGE

RAGE associated_with CD36

RAGE interacts_with CD47

RAGE activates CMKLR1

RAGE therapeutic_target STING