| Gene Symbol | SGK3 |
| Full Name | Serum/Glucocorticoid Regulated Kinase 3 |
| Chromosome | 8q12.3 |
| Protein Type | Kinase |
| Function | The kinase is activated by PDK1-mediated phosphorylation at Thr320, a site conserved across SGK family members [4]. |
| Subcellular Localization | distinguishes SGK3 from other SGK family members and is particularly relevant to [neurodegenerative disease mechanisms]( |
| Amino Acids | 644 aa |
| Exons | 14 |
| Pathways | PI3K, mTOR pathway, pi3k, mTOR |
| Ensembl ID | ENSG00000115297 |
| GeneCards | SGK3 |
| Human Protein Atlas | SGK3 |
| NDRG2 | A differentiation-related protein involved in neurite outgrowth |
| FOXO transcription factors | Regulates neuronal survival and stress responses |
| Tau protein | SGK3 can phosphorylate tau at multiple sites relevant to Alzheimer's disease pathology [5] |
| Associated Diseases | neurodegeneration |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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