Contents

Cdk5 (Cyclin-Dependent Kinase 5)

🔬 Protein Info

Gene Symbol	CDK5
Protein Family	CMGC kinase group, CDK family
Protein Type	Serine/Threonine Kinase
Function	Cdk5 knockout mice die at birth with severe cortical layering defects due to failed neuronal migration.
Primary Expression	Cytoplasm, nucleus, synapses, growth cones, perinuclear region
Amino Acids	291 aa
Pathways	Apoptosis, Autophagy, Checkpoint Inhibitor, Immune Checkpoint, Immune Response
GeneCards	CDK5
Human Protein Atlas	CDK5
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Ataxia
Known Drugs/Compounds	metformin, METFORMIN, N-ACETYLCYSTEINE, Protopanaxatriol, RESVERATROL
Interactions	ABETA, ACHE, Actin, AD, AGING, AKT
SciDEX Hypotheses	CDK5 Inhibition at Presynaptic Terminals Prevents
KG Connections	750 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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Knowledge Graph

DCX interacts_with CDK5

CDK5 interacts_with LIS1

CDK5 interacts_with DAB1

CDK5 interacts_with PAFAH1B1

CDK5 inhibits BECN1

PAFAH1B1 interacts_with CDK5

DAB1 interacts_with CDK5

LIS1 interacts_with CDK5

BACE1 inhibits CDK5

CDK5 associated_with DAB1