| Gene Symbol | BECN1 |
| Function | BECN1 encodes beclin-1, a key regulator of autophagy—a cellular process for degrading and recycling damaged organelles, protein aggregates, and intracellular pathogens. |
| Subcellular Localization | ** | Cytoplasm, Golgi apparatus, endoplasmic reticulum, mitochondria | |
| Molecular Weight | 60 kDa |
| Pathways | Akt, Apoptosis, Autophagy, Car-T, Epigenetic |
| UniProt ID | Q9Y5P6 |
| Ensembl ID | ENSG00000126581 |
| GeneCards | BECN1 |
| Human Protein Atlas | BECN1 |
| ATG Protein Recruitment | BECN1 interacts with the ATG12-ATG5-ATG16L1 conjugation system, facilitating the lipidation of LC3 and the expansion of the autophagosome membrane. |
| Synaptic Function | Autophagy regulated by BECN1 is essential for synaptic vesicle recycling, neurotransmitter release, and synaptic plasticity. Disrupted autophagy leads to impaired neurotransmission and synaptic loss. |
| Axonal Transport | BECN1-containing autophagosomes undergo retrograde transport along axons, enabling long-range degradation of cargo in the soma. This process is essential for axonal homeostasis. |
| Neurogenesis | During neural development and in adult neurogenic niches, BECN1 regulates the balance between neural stem cell proliferation and differentiation through selective autophagy of specific substrates. |
| Associated Diseases | AD, ALI, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | crocin, HCQ, Isorhapontigenin, nicotine, rapamycin, RAPAMYCIN |
| Interactions | ABCD3, ACAT1, ACETYL-COA, ACHE, ACOX1, ACTB |
| KG Connections | 3054 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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