| Gene Symbol | BAX |
| Chromosome | 19q13.33 |
| Protein Family | BCL-2 family (BH3-only pro-apoptotic) |
| Function | is a critical pro-apoptotic member of the BCL-2 protein family that plays a central role in regulating mitochondrial apoptosis. |
| Subcellular Localization | Cytosol (inactive), Mitochondria (active), ER |
| Molecular Weight | 21 kDa (192 amino acids) |
| Amino Acids | 192 aa |
| Pathways | Akt, Apoptosis, Autophagy, Cell Division, Cholesterol |
| UniProt ID | Q07812 |
| Ensembl ID | ENSG00000087088 |
| GeneCards | BAX |
| Human Protein Atlas | BAX |
| BH3 Domain | Critical for interaction with anti-apoptotic BCL-2 proteins and for activation of BAX itself |
| Canonical BCL-2 Fold | Nine alpha-helices arranged in a globular structure |
| C-terminal Transmembrane Domain | Targets BAX to mitochondrial outer membrane upon activation |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Ataxia |
| Known Drugs/Compounds | ABT-263, ANTHOCYANINS, berberine, BERBERINE, B.glomerulata, cadmium |
| Interactions | ABCG2, ACHE, ACSL4, ADAM8, AGING, AIF |
| KG Connections | 2395 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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