| Gene Symbol | EHMT2 |
| Full Name | Euchromatic Histone Lysine Methyltransferase 2 |
| Protein Type | Transferase |
| Function | EHMT2 (also known as G9a or KMT1C) is a histone lysine methyltransferase that catalyzes the mono- and dimethylation of histone H3 at lysine 9 (H3K9me1/2). |
| Primary Expression | Purkinje cells - Allen Brain Atlas: [EHMT2 expression data](https://human |
| Pathways | Apoptosis, apoptosis pathway |
| Ensembl ID | ENSG00000108799 |
| GeneCards | EHMT2 |
| Human Protein Atlas | EHMT2 |
| H3K9 Methylation | Adds H3K9me1/2 marks associated with gene silencing |
| H3K27 Methylation | Can also methylate H3K27 |
| Non-histone Targets | Methylates various non-histone proteins including TP53, RELA, and WIZ |
| Associated Diseases | ALS, Lymphoma |
| Known Drugs/Compounds | Cinobufagin |
| Interactions | APOPTOSIS, BCL-2, BCL2, CANCER, CASPASE3, DNA |
| KG Connections | 66 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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