gene 1,702 words KG: SOCS1
Contents

SOCS1 Gene

🧬 Gene Info
Gene SymbolSuppressor of Cytokine Signaling 1
Chromosome16p13.13
Protein TypeSOCS family negative regulator
Functionis a critical negative regulator of the JAK-STAT signaling pathway.
Primary ExpressionImmune cells, neurons, astrocytes, microglia, widespread
PathwaysJAK-STAT signaling
UniProt IDO35744
NCBI Gene ID8651
Ensembl IDENSG00000185338
OMIM603597
Associated DiseasesLymphoma, Ms
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AND, ANXIETY, APP, APP/PS1
KG Connections86 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Tau ASO Therapy
validation · proposed · Score: 0.40

See Also (15)

JAK Inhibitors in Parkinson's Disease
company · KG edge: inhibits
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: therapeutic_target
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: causes
Genes
index · KG edge: associated_with
ATG5 — Autophagy Related 5
gene · KG edge: activates

Knowledge Graph (12 edges)

FAS associated_with SOCS1
FASN associated_with SOCS1
SOCS1 associated_with PPARGC1A
EP300 expressed_in SOCS1
BCL2 associated_with SOCS1
TP53 therapeutic_target SOCS1
TET2 associated_with SOCS1
SGK1 associated_with SOCS1
MYD88 associated_with SOCS1
SOCS1 associated_with NOTCH2

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