gene 621 words KG: RAC2
Contents

RAC2 — RAS-Related C3 Botulinum Toxin Substrate 2

🧬 Gene Info
Gene SymbolRAC2
Full NameRAS-Related C3 Botulinum Toxin Substrate 2
Chromosome22q13.1
FunctionRAC2 is a small GTPase belonging to the Rho family.
Primary Expressionhematopoietic cells but also has significant expression in the nervous system, particularly in neurons and [microglia](/cell-type
Molecular Weight21.4 kDa
Amino Acids192 aa
UniProt IDP15153
NCBI Gene ID5879
Ensembl IDENSG00000128340
OMIM602049
GeneCardsRAC2
Human Protein AtlasRAC2
GTPase domainBinds GTP/GDP and has intrinsic GTPase activity
Effector regionInteracts with downstream targets
Associated DiseasesAtherosclerosis, Ms
InteractionsACTB, CAT, CCL5, CD19, CD4, CDK4
KG Connections35 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (1)

SASP-Mediated Complement Cascade Amplification
Score: 0.70

Related Analyses (2)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (10)

Viral and Post-Infectious Mechanisms in ALS — Experiment Des
clinical · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Genes
index · KG edge: associated_with
ACTB Gene
gene · KG edge: interacts_with
CAT — Catalase
gene · KG edge: interacts_with
CCL5 — C-C Motif Chemokine Ligand 5
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

RAC2 associated_with CTSD
RAC2 associated_with MAF
CD4 interacts_with RAC2
MAPK3 interacts_with RAC2
ZAP70 interacts_with RAC2
TP53 interacts_with RAC2
CD19 interacts_with RAC2
EEF2 interacts_with RAC2
CCL5 interacts_with RAC2
TNF interacts_with RAC2

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