| Gene Symbol | ATF2 |
| Full Name | Activating Transcription Factor 2 |
| Protein Type | Transcription Factor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 75 kDa |
| Pathways | Autophagy, Neurogenesis, Epigenetic, Mitochondrial Function, Pi3K/Akt |
| GeneCards | ATF2 |
| Human Protein Atlas | ATF2 |
| bZIP domain | Basic region for DNA binding, leucine zipper for dimerization |
| DNA-binding specificity | Recognizes ATF/CRE (TGACGTCA) and AP-1 (TGACTCA) sites |
| Protein interaction domains | Binds to CBP/p300 coactivators |
| Cell survival | BCL-2, IAPs |
| Stress response | HSP70, GADD45 |
| Inflammation | IL-6, IL-8, TNF-α |
| synaptic plasticity | CREB-dependent genes |
| Associated Diseases | Als, Ataxia, Dystonia, Huntington, Ms, Parkinson |
| Known Drugs/Compounds | metformin |
| Interactions | ACSL4, AGING, AND, APOPTOSIS, ATP, AUTOPHAGY |
| KG Connections | 87 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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