| Gene Symbol | LZTS1 |
| Full Name | Leucine Zipper Tumor Suppressor 1 |
| Chromosome | 8 |
| Function | Leucine Zipper Tumor Suppressor 1 (LZTS1) is a putative tumor suppressor protein that contains multiple leucine zipper motifs and is involved in cell cycle regulation, cell migration, and neuronal dev |
| Pathways | Apoptosis, Wnt, Mapk |
| Ensembl ID | ENSG00000061337 |
| GeneCards | LZTS1 |
| Human Protein Atlas | LZTS1 |
| Cell cycle regulation | LZTS1 interacts with the ubiquitin-proteasome system to promote degradation of cyclin D1, controlling G1/S transition[@uno2022] |
| Actin cytoskeleton organization | LZTS1 localizes to the cytoskeleton and regulates cell migration and adhesion |
| Neuronal development | In the developing brain, LZTS1 regulates neurite outgrowth and axonal guidance through interactions with the actin cytoskeleton |
| Brain | High expression in cerebral cortex, hippocampus (CA1-CA3 pyramidal cells), and cerebellum |
| Neuronal expression | Localizes to dendritic shafts and growth cones during development |
| Cellular localization | Cytoplasmic and cytoskeletal, with nuclear localization in dividing cells |
| Associated Diseases | Aging, Als, Alzheimer, Dementia, Ms |
| Interactions | APOPTOSIS, CANCER, CD44, FGF10, KCNH1, KCNK2 |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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