gene 649 words KG: DLC1
Contents

DLC1 Gene - Deleted in Liver Cancer 1

🧬 Gene Info
Gene SymbolDLC1
AliasesPage for DLC1 Gene
Chromosome8p22.
FunctionDLC1 (Deleted in Liver Cancer 1) is a GTPase-activating protein (GAP) that specifically inactivates Rho family GTPases, primarily RhoA, Rac1, and Cdc42.
Primary Expressiondopaminergic neurons where it may protect against oxidative stress
PathwaysApoptosis, Wnt, Mapk
Ensembl IDENSG00000121667
GeneCardsDLC1
Human Protein AtlasDLC1
Associated Diseasesneurodegeneration
InteractionsAPOPTOSIS, CANCER, CD44, FGF10, KCNH1, KCNK2
KG Connections25 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
TLR4 (Redirect)
redirect · KG edge: inhibits
Tumor Necrosis Factor (TNF)
entity · KG edge: inhibits
CD44 - Cell Surface Glycoprotein
gene · KG edge: inhibits

Knowledge Graph (12 edges)

CDKN2A associated_with DLC1
TLR4 inhibits DLC1
TNC inhibits DLC1
NTRK2 inhibits DLC1
PAK1 inhibits DLC1
WNT7A associated_with DLC1
LZTS1 associated_with DLC1
DCC associated_with DLC1
KCNK2 inhibits DLC1
CD44 inhibits DLC1

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