SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
gene 839 words KG: APOC2
Contents

APOC2 Gene

🧬 Gene Info
Gene SymbolAPOC2
Chromosome19q13.32
FunctionLPL Activation: APOC2 is the essential cofactor for lipoprotein lipase
Primary Expressionthe liver and small intestine
Molecular Weight8.8 kDa
Amino Acids79 aa
Exons4
PathwaysCholesterol
Ensembl IDENSG00000134901
GeneCardsAPOC2
Human Protein AtlasAPOC2
Nutritional statusIncreased by high-carbohydrate diets
InsulinSuppresses APOC2 expression
PPAR agonistsFibrates modulate APOC2 levels
Inflammatory cytokinesTNF-α and IL-6 reduce expression
Associated DiseasesAging, Als, Alzheimer, Dementia, hypertriglyceridemia, Ms
InteractionsABCA1, ABCA2, APOA1, APOC1, APOC3, APOD
KG Connections117 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72CYP46A1 Overexpression Gene Therapy
Score: 0.73Membrane Cholesterol Gradient Modulators
Score: 0.71Complement C1q Mimetic Decoy Therapy
Score: 0.69Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69Ganglioside Rebalancing Therapy
Score: 0.69LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSynaptic pruning by microglia in early AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

nct05508789
clinical_trial · Pages share 9 hypothesesLX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypothesesUPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypothesesremternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypothesesLX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

Knowledge Graph (12 edges)

COL4A1 associated_with APOC2
LZTS1 associated_with APOC2
APOE4 associated_with APOC2
APOA2 associated_with APOC2
APOC2 associated_with MCC
APOC2 associated_with CAT
APOC2 associated_with APOA1
APOC2 causes hypertriglyceridemia
APOC2 activates JAK-STAT signaling pathway
APOC2 associated_with LZTS1

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.
SciDEX — scidex.ai — Dashboard | Atlas