gene 1,750 words KG: ITGAM
Contents

ITGAM Gene

🧬 Gene Info
Gene SymbolITGAM
Protein TypeReceptor
Functionis a multifunctional immune receptor that binds complement fragment iC3b, ICAM-family ligands, fibrinogen, and damage-associated molecular patterns.
Amino Acids1153 aa
PathwaysComplement
Ensembl IDENSG00000169896
GeneCardsITGAM
Human Protein AtlasITGAM
Associated DiseasesAging, Als, Alzheimer, Parkinson's disease, Senescence
InteractionsAIF1, AND, APOPTOSIS, C1QA, C1QB, C1QC
SciDEX HypothesesITGAM/CD11b direct binding explains microglial pha
KG Connections203 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
← Prevpg 2/2

Related Analyses (7)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

See Also (13)

AIF1 Gene
gene · KG edge: biomarker_for
C1QA Gene
gene · KG edge: biomarker_for
C1QB — Complement Component 1Q Beta
gene · KG edge: biomarker_for
C1QC
gene · KG edge: activates
C1R — Complement Component 1, R Subcomponent
gene · KG edge: regulates

Knowledge Graph (12 edges)

ICAM1 activates ITGAM
TREM2 activates ITGAM
TLR2 activates ITGAM
NFKBIA activates ITGAM
MRC1 activates ITGAM
IL1B activates ITGAM
ITGAM activates TNF
ITGAM activates CXCL2
ITGAM activates CD14
ITGAM activates PPARG

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