gene 3,026 words KG: GSK3B
Contents

GSK3B Gene - Glycogen Synthase Kinase 3 Beta

🧬 Gene Info
Gene SymbolGSK3B
AliasesGSK-3β, TPKII, Tau tubulin kinase (TTBK)
Chromosome3q13.33
Protein TypeSerine/Threonine Kinase
Functionis a constitutively active serine/threonine kinase encoded by the GSK3B gene that plays central and multifaceted roles in cellular physiology[@woodgett1990].
Molecular Weight47 kDa (420 amino acids)
Amino Acids420 aa
Exons12
PathwaysAkt, Cholesterol, Mapk, Microrna, Nf-Kb
GeneCardsGSK3B
Human Protein AtlasGSK3B
Associated DiseasesAging, ALS, Alzheimer, Alzheimer's disease, APOPTOSIS
Known Drugs/CompoundsANTHOCYANINS, Ficus deltoidea, LITHIUM, rapamycin, RAPAMYCIN, SB216763
InteractionsABCA1, ACETYL-COA, ACHE, Actin, AD, ADAM17
KG Connections1182 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (27)

TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
← Prevpg 2/2

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (6)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCA2 Gene - ATP Binding Cassette Subfamily A Member 2
gene · KG edge: regulates
ADRB2 Gene
gene · KG edge: interacts_with
AIFM1 Gene
gene · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

C3 regulates GSK3B
TCF4 associated_with GSK3B
MYC associated_with GSK3B
LC3 associated_with GSK3B
MTOR associated_with GSK3B
BECN1 associated_with GSK3B
CTNNB1 associated_with GSK3B
AXIN2 associated_with GSK3B
GAPDH associated_with GSK3B
SQSTM1 associated_with GSK3B

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